Abstract: As an important medium, soil environment has a close relation to human beings, and there is increasingly concern about the soil environment. Monitoring the soil geo-environment is important. Soil monitoring network must be economic and reasonable, which is needed to resolve scientifically. In this paper, soil region monitoring network optimized by spatial autocorrelation is examined in the Baoding-Cangzhou area. The results show that one soil monitoring point per 64 km2 is a reasonable density in the Baoding-Cangzhou area. With this density, soil geochemical information can be caught and maintained effectively.