Abstract: Rational design of exploitation schemes is of great significance to the development of groundwater resources along a river. The study area is located in Dehui, which is a typical region along a river. Based on the survey of hydrogeological conditions in the study area, analytic methods are used to determine the optimal exploitation scheme and the allowable groundwater yield by the tube wells. The rationality and reliability of the optimal exploitation scheme are also analyzed. The results show that 12 pumping wells is in a straight line along the river with the distance between wells of 150 m. The distance between the wells and the river is 200 m. The pumping rate of a single well is 2 960 m3/d, while the total amount of groundwater exploitation is 35 520 m3/d. The exploitation scheme not only has higher water supply reliability, but also has a certain ability to withstand the sudden pollution of river. Meanwhile, this scheme will not cause great impact on the regional water environment and other users.