Abstract: It is rare that a 28 meter vertical slope of the highway’s roadbed is formed in need of topography and planning.Anti-slide piles with pre-stress anchor cable were adopted for reinforcement of the slope,the length of piles is 39 meter,and the most cantilever height of piles is 28 meter.Anchor cables of three anti-slide piles(7#、2#、4#) have been regularly tested since they were tensioned. Quantity of the pre-stress loss of anchor cable of the anti-slide piles was calculated for construction safety and normal operation of landslide with remedial work,each factor which affects the pre-stress loss of anchor cable in system was analyzed in the paper,it provides theoretical basis for the design and management of the anchor cables thereafter.