Abstract: The types of geological disasters in southern China are diverse and widely distributed, which are closely related to the complex and changeable geological environment conditions. It is of great significance to reveal the spatial differentiation law of regional geological environment for disaster prevention and mitigation. In this paper, the expert scoring method, analytic hierarchy process (AHP) and K-means clustering method are used to complete the division of the first-class, second-class and third-class disaster pregnant geological environment in 15 provinces and cities in the South based on the factors such as landform, formation lithology, geological disaster distribution and human engineering activities, and morphological filtering is used for post-processing. According to the proposed multi-scale disaster prone geological environment zoning system, 15 provinces in southern China are divided into 8 first-class zoning, 40 second-class zoning and 268 third-class zoning. The zoning results of disaster pregnant geological environment conform to the natural geographical boundaries and have good interpretability. The grade of disaster pregnant geological environment is negatively correlated with the density characteristics of geological disasters, which verifies the scientific and rationality of the zoning results of disaster pregnant geological environment. The multi-scale disaster prone geological environment zoning system not only realizes the hierarchical expression of disaster prone geological environment in 15 provinces and cities in southern China, but also provides reliable technical support for the evaluation of geological disaster susceptibility in southern China.