Abstract: Under flowing water conditions, water-sand mixture inrush in metal mines are highly destructive and sudden, posing a significant threat to mine safety. Effective and reliable treatment technologies remain underdeveloped. This study utilized a physical model, to visualize the grouting process and acquire relevant data. This research aims to investigate the diffusion, filling, and consolidation characteristics of grout in fractured rock masses under flowing-water conditions at the Cuihongshan iron polymetallic mine, and to validate and optimize a cement-sodium silicate two-liquid grouting system. Results demonstrated that: (1) grouting sequence significantly influenced grout diffusion rate and extent. Early-stage grouting exhibited rapid diffusion but low consolidation ratios. The three grouting stages (Z1, Z2, and Z3) sequentially presented ascending, arched, and basin-shaped patterns with consolidation ratios of 50%, 80%, and 90%, respectively. The Z1 and Z2 stages exhibited a slow-fast-slow grouting rate pattern, whereas Z3 exhibited slow, uniform diffusion and filling, confirming the necessity of secondary borehole grouting. (2) Soil pressure increases correlated positively with grouting pressure, volume, and depth, with an average increase of 724 kPa after grouting. Osmotic pressure increased by averages of 1.91 kPa, 1.45 kPa, and 0.57 kPa, respectively, exhibiting a multi-peak pattern in Z1 and Z2 and a plateau pattern in Z3, indicating significant water sealing and reinforcement effects. Complete water blockage was achieved in the Z2 stage, transitioning the grouting environment to static conditions and suggesting a necessary adjustment to field treatment strategies. (3) Based on pressure similarity ratios, the maximum grouting pressures for primary and secondary boreholes in field applications were determined to be 0.5 MPa and 0.3 MPa, respectively. Key criteria for evaluating grouting effectiveness were established. (4) The grouting pressure and flow-rate trends observed in field applications closely matched the model test results, and multiple evaluation indicators confirmed that treatment efficacy met the engineering design requirements. This study validates the precise guidance provided by the experimental model for field treatment and offers essential theoretical and technical support for treating water-sand mixture inrush in metal mines.