Abstract: As one of the famous karst springs in northern China, the Niangziguan Spring was much examined. Infiltration of precipitation is the main recharge source of the karst groundwater. Research on the infiltration coefficient of precipitation is of important significance for the karst groundwater resource evaluation and spring flow analyses. The major achievements of the infiltration coefficient of precipitation are based on the water balance method in the karst groundwater system. The precipitation recharge is given through the water-budget equation, and the results will decrease with the increasing karst groundwater system. This method can cause errors because of the uncertainty of the karst groundwater system. Chloride mass balance (CMB) is a simple and valid estimation method of recharge from precipitation, and it has widely been used at home and abroad. In the Niangziguan karst spring area, two typical karst regions were separately selected in the outcropping areas of the carbonates and the covered carbonate areas. The CMB were adopted to estimate the vertical infiltration coefficient at these two regions, and the results are 0.21 at outcropping carbonate area and 0.11 at covered carbonate area. The results are in a good agreement with the data from the predecessors. This paper contributes to promote the applications and developments of the CMB method in karst areas in northern China.